Buffalo (pop: 292,648) is New York's second largest city and metropolitan area at around 1.25 million people (with Niagara Falls). Famous for the Bills, chicken wings, and the University of Buffalo, the city has an international border with Fort Erie, Ontario, a downtown with some of the best architecture in the country, the funky Allentown, and the Buffalo Botanical Gardens. Plus, it's not too far from Niagara Falls. Buffalo, the Second City of New York.